Ginsenoside Rk1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

人参皂苷 Rk1 是通过高温加工人参植物而产生的成分。 Ginsenoside Rk1 具有抗炎作用，抑制 Jak2/Stat3 信号通路和 NF-κB 的激活。它还具有抗肿瘤作用。

Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB. It also has an anti-tumor effect.

Ginsenoside Rk1 (0-40 μM; 6 hours) inhibits MCP-1 and TNF-α mRNA induced by lipopolysaccharide (LPS), expression of IL-1β is inhibited at 40 μM.Ginsenoside Rk1 (0-40 μM; 24 hours) inhibits phosphorylation of JAK2 and STAT3 (Tyr705 and Ser727) in LPS-induced RAW264.7 cells in a dose-dependent manner.Ginsenoside Rk1 (0-160 μM; 48 hours) results in cell viability significant decrease 75.52 ± 2.51% (40 μM), 52.72 ± 2.54% (80 μM), 17.41 ± 2.94% (120 μM)and 12.63 ± 3.24% (160 μM) compared with control.Ginsenoside Rk1 (0-120 μM; 24 hours) increases G0/G1 phase proportion accompanied with S and G2/M phase proportion decrease in MDA-MB-231 cells.Ginsenoside Rk1 (0-120 μM; 24 hours) promotes the percentage of apoptotic cells in a dose-dependent manner, exhibits to reduction of cell number with nucleus fragmentation, condensation and apoptotic body formation. RT-PCR Cell Line:RAW264.7 cells Concentration:10 μM, 20 μM, 40 μM Incubation Time:6 hours Result: Inhibited JAK2-dependent STAT3 activation in LPS-activated RAW264.7 cells.Western Blot Analysis Cell Line:RAW264.7 cells Concentration:10 μM, 20 μM, 40 μM Incubation Time:6 hours Result:Inhibited JAK2-dependent STAT3 activation in LPS-activated RAW264.7 cells Cell Viability Assay Cell Line:MDA-MB-231 cells Concentration:0 μM, 40 μM, 80 μM, 120 μM Incubation Time:48 hours Result:Inhibited MDA-MB-231 cells proliferation in a dose- and time-dependent manner.Cell Cycle Analysis Cell Line:MDA-MB-231 cells Concentration:0 μM, 40 μM, 80 μM, 120 μM Incubation Time:24 hours Result:Induced G0/G1 phase arrest.Apoptosis Analysis Cell Line:MDA-MB-231 cells Concentration:0 μM, 40 μM, 80 μM, 120 μM Incubation Time:24 hours Result:Induced apoptosis in MDA-MB-231 cells.

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494753-69-4

767.01

C42H70O12

>98% (HPLC)

DMSO: 90 mg/mL (117.34 mM)

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(-20℃)

With Ice Pack

≥ 2 years